Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART During Acute HIV-1

This study tests a three-drug immune-based treatment strategy for people who started HIV treatment very early (within 90 days of being diagnosed with acute HIV infection). Researchers want to see whether this combination can train the immune system to better control HIV, with the goal of one day allowing people to reduce or pause treatment. **You may be eligible if...** - You started HIV antiretroviral therapy (ART) within 90 days of being diagnosed with early HIV - You have been on ART continuously for at least 12 months - Your current ART includes an integrase inhibitor - You are willing to participate in a monitored treatment interruption - Your viral load is undetectable and immune cell counts are healthy **You may NOT be eligible if...** - You have serious chronic illness other than HIV - You have a history of certain cancers or serious immune conditions - You are pregnant or breastfeeding - You have missed more than 28 consecutive days of ART in the past year Talk to your doctor to see if this trial is right for you.