RecruitingNCT06073314

Novel Applications for Sarcoma Assessment

Sponsor

The Leeds Teaching Hospitals NHS Trust

Enrollment

250 participants

Start Date

Aug 9, 2023

Study Type

OBSERVATIONAL

Conditions

Sarcoma

Summary

This research aims to improve the way of deciding whether a lump in soft tissue such as fat or muscle is a type of cancer called a soft tissue sarcoma, or if it is benign (non-cancerous). To do this the investigators will use routine clinical MRI scans, additional quantitative MRI scans and artificial intelligence. The aims of this research are: To develop AI algorithms that can accurately classify soft tissue masses as benign or malignant using routine and quantitative MR images. To classify malignant soft tissue masses into their pathological grade. Compare different AI models on external, unseen testing sets to determine which offers the best performance. Participants will be asked if they can spend up to a maximum of 10 extra minutes in an MRI scanner so that the extra images can be acquired. A small subset of participants will be invited back so the investigators can check the reproducibility of the images and the AI software.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests new ways to use MRI scans to better assess and characterize soft tissue masses that may be sarcoma. Researchers want to find imaging features that can help doctors determine whether a mass is cancerous and what type it is — without relying solely on biopsy. **You may be eligible if...** - You have a soft tissue mass being discussed at a sarcoma specialist team meeting - You are already scheduled for an MRI as part of your standard care - You are able to give informed consent to participate **You may NOT be eligible if...** - Your mass has already been surgically removed (completely or partially) before your MRI - You have a contraindication to MRI (such as a pacemaker, incompatible implant, or severe claustrophobia) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTQuantitative MRI

Patients will be asked to remain in the scanner for an additional 10 minutes while we acquire additional quantitative MR images

DIAGNOSTIC_TESTReproducibility study

A subset of patients will be invited back for a repeat MRI scan (prior to any treatment for their condition) to help measure reproducibility of our Artificial Intelligence model