LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia
Longitudinal Observational Trial to Uncover Subtypes of Cancer Cachexia
University of Rochester
800 participants
Dec 4, 2023
OBSERVATIONAL
Conditions
Summary
This study evaluates cancer-related weight and muscle mass loss, symptoms, and physical function (cachexia) in patients undergoing treatment for colorectal, lung, or pancreatic cancer that cannot be removed by surgery (unresectable) or is stage IV. Patients with these cancer types are at risk for developing cancer cachexia (CC), which is defined as weight loss, muscle loss, and fat loss due to cancer. CC has been associated with reduced physical performance, impaired quality of life, and poorer survival. Many studies that have evaluated treatments for cancer-related weight and muscle loss have aimed to treat all patients with weight loss exactly the same and, unfortunately, have not been successful. Like different cancer types, weight and muscle loss related to cancer may have different causes in different individuals and the best treatment strategy for this condition may not be a one-size-fits-all approach. Information gathered from this study may help researchers develop new diagnostic criteria for CC and design better treatments and clinical trials for cancer-related weight and muscle loss in the future to improve the quality of life in patients with advanced colorectal, lung, or pancreatic cancer.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Undergo collection of blood and archived tumor samples
Undergo CT or PET/CT scan
Medical records reviewed
Wear actigraph
Undergo physical function tests
Undergo PET/CT scan
Complete surveys
Locations(225)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06073431