RecruitingNot ApplicableNCT06079294

Impact of Confirmed Autoimmune Encephalitis on Brain Glucose Metabolism

Impact of Confirmed Autoimmune Encephalitis on Brain Glucose Metabolism : a Prospective FDG PET Study

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

56 participants

Start Date

May 31, 2024

Study Type

INTERVENTIONAL

Conditions

Autoimmune Encephalitis

Summary

Prospective cohort study evaluating FDG PET in 56 patients with confirmed autoimmune encephalitis - based on 2016 Graus criteria, and 2021 paraneoplastic neurological syndromes criteria - at the acute phase, before immunomodulating treatment, or within 10 days of treatment initiation.

Eligibility

Min Age: 18 Years

Inclusion Criteria8

Age ≥ 18 years old
Newly diagnosed autoimmune encephalitis based on at least 1 of the 3 following criteria :
" Definite limbic autoimmune encephalitis " according to 2016 Graus et al. criteria
" Possible autoimmune encephalitis " according to 2016 Graus et al. criteria AND typical autoantibody detected in serum or CSF
" Probable or certain paraneoplastic neurological syndrome " according to Graus et al. 2021 criteria (excluding peripheral neurological syndromes)
Less than 6 months since first neurological symptoms imputable to autoimmune encephalitis
Affiliated or entitled to a social security system (except AME)
Obtaining free, written and informed consent (patient or legal representative or the close relative)

Exclusion Criteria9

History of brain tumor, head trauma, infarction or cerebral hematoma likely to result in altered cerebral carbohydrate metabolism on PET
Patients who hae been on immunotherapy (corticosteroid bolus, IVIg, plasma exchange, endoxan, rituximab or other immunotherapy) fr more than 10 days
Pregnant or breast-feeding woman
Ventilated intubated patient
Absolute contraindication to MRI (Pacemaker, cochlear implant, etc.)
Presence of cognitive disorders incompatible with goog cooperation with the PET scan
Algic or agitated patient unable to remain immobile in supine position for 30 minutes
Deprived of liberty or under a protective measure (guardianship or curatorship)
Patient taking part in other interventional research involving radiopharmaceutical injections

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