RecruitingPhase 3NCT06079671

Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical)

A Phase III, Randomized, Double-blind, Placebo-controlled, Multi-centre, Global Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer Who Have Not Progressed Following Platinum-based, Concurrent Chemoradiation Therapy (eVOLVE-Cervical)

Sponsor

AstraZeneca

Enrollment

800 participants

Start Date

Sep 22, 2023

Study Type

INTERVENTIONAL

Conditions

Locally Advanced Cervical Cancer

Summary

This is a phase III, randomized, double-blind, placebo-controlled, multi-center, global study to explore the efficacy and safety of volrustomig in women with high-risk LACC (FIGO 2018 stage IIIA to IVA cervical cancer) who have not progressed following platinum-based CCRT.

Eligibility

Sex: FEMALEMin Age: 15 Years

Plain Language Summary

Simplified for easier understanding

This study (eVOLVE-Cervical) is testing volrustomig — a new immunotherapy drug that blocks two immune checkpoint proteins (PD-1 and CTLA-4) — in women with high-risk, locally advanced cervical cancer as part of their standard chemoradiation treatment. **You may be eligible if...** - You are female and at least 15 years old (younger participants need to be at a certain stage of physical development) - You weigh more than 35 kg - You have been diagnosed with FIGO 2018 Stage IIIA to IVA cervical cancer (advanced but not yet spread to distant organs) confirmed by tissue testing - Your cancer is adenocarcinoma, squamous carcinoma, or adenosquamous carcinoma of the cervix **You may NOT be eligible if...** - You are outside the eligible age range - Your cancer is a different type or stage - You have already received systemic treatment for cervical cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BIOLOGICALVolrustomig

IV Infusion

OTHERPlacebo

IV Infusion

Locations(204)

Research Site

Birmingham, Alabama, United States

Research Site

Phoenix, Arizona, United States

Research Site

Tucson, Arizona, United States

Research Site

Little Rock, Arkansas, United States

Research Site

La Jolla, California, United States

Research Site

West Hollywood, California, United States

Research Site

Atlanta, Georgia, United States

Research Site

Augusta, Georgia, United States

Research Site

Savannah, Georgia, United States

Research Site

Melrose Park, Illinois, United States

Research Site

Indianapolis, Indiana, United States

Research Site

New Orleans, Louisiana, United States

Research Site

New Orleans, Louisiana, United States

Research Site

Shreveport, Louisiana, United States

Research Site

New York, New York, United States

Research Site

Syracuse, New York, United States

Research Site

Cleveland, Ohio, United States

Research Site

Columbus, Ohio, United States

Research Site

Eugene, Oregon, United States

Research Site

Philadelphia, Pennsylvania, United States

Research Site

Providence, Rhode Island, United States

Research Site

Dallas, Texas, United States

Research Site

Fort Worth, Texas, United States

Research Site

Houston, Texas, United States

Research Site

Tyler, Texas, United States

Research Site

Charlottesville, Virginia, United States

Research Site

Fairfax, Virginia, United States

Research Site

Richmond, Virginia, United States

Research Site

Barretos, Brazil

Research Site

Belo Horizonte, Brazil

Research Site

Curitiba, Brazil

Research Site

Fortaleza, Brazil

Research Site

Fortaleza, Brazil

Research Site

Goiânia, Brazil

Research Site

Natal, Brazil

Research Site

Porto Alegre, Brazil

Research Site

Porto Alegre, Brazil

Research Site

Porto Alegre, Brazil

Research Site

Porto Velho, Brazil

Research Site

Recife, Brazil

Research Site

Rio de Janeiro, Brazil

Research Site

Salvador, Brazil

Research Site

São Paulo, Brazil

Research Site

São Paulo, Brazil

Research Site

São Paulo, Brazil

Research Site

Teresina, Brazil

Research Site

Hamilton, Ontario, Canada

Research Site

London, Ontario, Canada

Research Site

Toronto, Ontario, Canada

Research Site

Toronto, Ontario, Canada

Research Site

Montreal, Quebec, Canada

Research Site

Montreal, Quebec, Canada

Research Site

Ste-Foy, Quebec, Canada

Research Site

Beijing, China

Research Site

Beijing, China

Research Site

Beijing, China

Research Site

Changde, China

Research Site

Changsha, China

Research Site

Changsha, China

Research Site

Chengdu, China

Research Site

Chengdu, China

Research Site

Chongqing, China

Research Site

Fuzhou, China

Research Site

Ganzhou, China

Research Site

Guangzhou, China

Research Site

Guangzhou, China

Research Site

Hangzhou, China

Research Site

Harbin, China

Research Site

Kunming, China

Research Site

Lanzhou, China

Research Site

Lanzhou, China

Research Site

Linyi, China

Research Site

Luzhou, China

Research Site

Nanchang, China

Research Site

Nanchang, China

Research Site

Shandong, China

Research Site

Shanghai, China

Research Site

Shanghai, China

Research Site

Shenyang, China

Research Site

Shenzhen, China

Research Site

Shenzhen, China

Research Site

Tianjin, China

Research Site

Wuhan, China

Research Site

Wuhan, China

Research Site

Xi'an, China

Research Site

Yibin, China

Research Site

Yinchuan, China

Research Site

Zhengzhou, China

Research Site

Zhengzhou, China

Research Site

Zhuzhou, China

Research Site

Aarhus N, Denmark

Research Site

København Ø, Denmark

Research Site

Odense, Denmark

Research Site

Berlin, Germany

Research Site

Bonn, Germany

Research Site

Hamburg, Germany

Research Site

Leipzig, Germany

Research Site

Calicut, India

Research Site

Jaipur, India

Research Site

Lucknow, India

Research Site

Madurai, India

Research Site

Mohali, India

Research Site

Nagpur, India

Research Site

Nashik, India

Research Site

Nashik, India

Research Site

New Delhi, India

Research Site

Vadodara, India

Research Site

Bari, Italy

Research Site

Bologna, Italy

Research Site

Catania, Italy

Research Site

Florence, Italy

Research Site

Lecco, Italy

Research Site

Milan, Italy

Research Site

Milan, Italy

Research Site

Milan, Italy

Research Site

Monza, Italy

Research Site

Naples, Italy

Research Site

Roma, Italy

Research Site

Rome, Italy

Research Site

Turin, Italy

Research Site

Fukuoka, Japan

Research Site

Ginowan-shi, Japan

Research Site

Hidaka-shi, Japan

Research Site

Kagoshima, Japan

Research Site

Kōtoku, Japan

Research Site

Kurume-shi, Japan

Research Site

Maebashi, Japan

Research Site

Matsuyama, Japan

Research Site

Morioka, Japan

Research Site

Nagoya, Japan

Research Site

Osaka, Japan

Research Site

Sapporo, Japan

Research Site

Sapporo, Japan

Research Site

Shinjuku-ku, Japan

Research Site

Suita-shi, Japan

Research Site

Sunto-gun, Japan

Research Site

Toon-Shi, Japan

Research Site

Coyoacán, Mexico

Research Site

Culiacán, Mexico

Research Site

Guadalajara, Mexico

Research Site

Guadalajra, Mexico

Research Site

Mexico City, Mexico

Research Site

México, Mexico

Research Site

México, Mexico

Research Site

Monterrey, Mexico

Research Site

Oslo, Norway

Research Site

Trondheim, Norway

Research Site

Concepción, Peru

Research Site

Lima, Peru

Research Site

Lima, Peru

Research Site

Lima, Peru

Research Site

Lima, Peru

Research Site

Lima, Peru

Research Site

Lima, Peru

Research Site

Bialystok, Poland

Research Site

Gdansk, Poland

Research Site

Gliwice, Poland

Research Site

Krakow, Poland

Research Site

Lodz, Poland

Research Site

Poznan, Poland

Research Site

Warsaw, Poland

Research Site

Wroclaw, Poland

Research Site

San Juan, Puerto Rico

Research Site

Daegu, South Korea

Research Site

Goyang-si, South Korea

Research Site

Gyeonggi-do, South Korea

Research Site

Seoul, South Korea

Research Site

Seoul, South Korea

Research Site

Seoul, South Korea

Research Site

Seoul, South Korea

Research Site

A Coruña, Spain

Research Site

Barcelona, Spain

Research Site

Barcelona, Spain

Research Site

Córdoba, Spain

Research Site

Girona, Spain

Research Site

Hospitalet deLlobregat, Spain

Research Site

Madrid, Spain

Research Site

Madrid, Spain

Research Site

Madrid, Spain

Research Site

Madrid, Spain

Research Site

Palma de Mallorca, Spain

Research Site

Valencia, Spain

Research Site

Valencia, Spain

Research Site

Changhua, Taiwan

Research Site

Kaohsiung City, Taiwan

Research Site

Kaohsiung City, Taiwan

Research Site

New Taipei City, Taiwan

Research Site

Taichung, Taiwan

Research Site

Taichung, Taiwan

Research Site

Tainan, Taiwan

Research Site

Taipei, Taiwan

Research Site

Taipei, Taiwan

Research Site

Taoyuan, Taiwan

Research Site

Bangkok, Thailand

Research Site

Bangkok, Thailand

Research Site

Bangkok, Thailand

Research Site

Muang, Thailand

Research Site

Udon Thani, Thailand

Research Site

Adana, Turkey (Türkiye)

Research Site

Ankara, Turkey (Türkiye)

Research Site

Ankara, Turkey (Türkiye)

Research Site

Cordaleo, Turkey (Türkiye)

Research Site

Istanbul, Turkey (Türkiye)

Research Site

Istanbul, Turkey (Türkiye)

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06079671

Related Trials

A Clinical Study of Nanocrystalline Megestrol Acetate in Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer

NCT073384871 location

MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial

NCT059755931 location

Neoadjuvant Iparomlimab and Tuvonralimab Plus Chemotherapy-eclipse for Locally Advanced Cervical Cancer (NICE-CC)

NCT070553991 location

Neoadjuvant Chemotherapy Plus Cadonilimab for Locally Advanced Cervical Cancer

NCT071041491 location

Study on Disease Characteristics and Treatment in Locally Advanced or Recurrent / Metastatic Cervical Cancer in Italy

NCT0677119311 locations