RecruitingPhase 2NCT07104149

Neoadjuvant Chemotherapy Plus Cadonilimab for Locally Advanced Cervical Cancer

Neoadjuvant Chemotherapy Plus Cadonilimab for Locally Advanced Cervical Cancer : a Multicentre, Single Arm, Phase 2 Trial


Sponsor

The First Affiliated Hospital of Zhengzhou University

Enrollment

29 participants

Start Date

Mar 10, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Main Purpose of this study is to determine the efficacy and safety of Cadonilimab combined with chemotherapy (cisplatin) for locally advanced cervical cancer. This is an multicentre, single Arm, Phase 2 Trial study of Cadonilimab with Cisplatin in the treatment of locally advanced cervical cancer. 29 eligible patients will receive Cadonilimab(10mg/kg, iv., D1, q3w)with Cisplatin ( 75mg/ m2, iv., D2, q3w) for a total of 2-4 cycles before radical surgical treatment.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether adding cadonilimab — a dual immunotherapy drug — to chemotherapy before surgery can improve outcomes for women with locally advanced cervical cancer that doctors believe can still be removed surgically. **You may be eligible if...** - You are a woman aged 18 or older - You have been diagnosed with cervical cancer at stage IB3, IIA2, IIB, or IIIC, confirmed by biopsy - Your cancer has not been treated with any prior chemotherapy, radiation, or surgery for this diagnosis - Your surgeon believes the cancer can be removed with radical surgery - Your blood counts, liver, and kidney function are in acceptable range **You may NOT be eligible if...** - You have received any prior treatment for this cervical cancer - Your overall health is too poor or your organ function is compromised - You have active autoimmune disease or are on long-term steroids Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGCadonilimab combined with cisplatin

Neoadjuvant chemotherapy plus cadonilimab for locally advanced cervical cancer


Locations(1)

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07104149


Related Trials