The Choice of Treatment Methods and Efficacy of LABC

This study looks at the best combination of treatments — surgery, radiation, and chemotherapy — for women with locally advanced breast cancer (a larger or more involved tumor that hasn't spread to distant parts of the body). Researchers are tracking how well these approaches work and how they affect quality of life. **You may be eligible if...** - You are a woman between 18 and 70 years old - You have been newly diagnosed with locally advanced breast cancer (stage IIIb or IIIc) - Your tumor may be removable with surgery - You are willing to receive surgery, radiation, and chemotherapy - You are willing to complete quality-of-life questionnaires during follow-up **You may NOT be eligible if...** - You have already had breast cancer treatment (surgery, radiation, or chemotherapy) - You have a history of another cancer - You are pregnant or breastfeeding - You have a serious infection, fever, or major health conditions such as heart/lung/liver/kidney disease or poorly controlled diabetes Talk to your doctor to see if this trial is right for you.