RecruitingNot ApplicableNCT06080659

Network-based biOmarker Discovery of Neurodegenerative Diseases Using Multimodal Connectivity

Sponsor

Rennes University Hospital

Enrollment

120 participants

Start Date

Nov 6, 2023

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease Alzheimer Disease, Early Onset

Summary

The aim of the NODAL clinical trial is to demonstrate the feasibility of new, low-cost, non-invasive biomarkers of neurodegenerative pathologies as early Alzheimer and Parkinson, based on the estimation of the multimodal connectome.

Eligibility

Min Age: 50 YearsMax Age: 80 Years

Inclusion Criteria15

For all participants:
French mother tongue
right-handed
with a level of education equal to or higher than the Certificat d'Études Primaires (Primary School Certificate)
Free of any medical or psychiatric condition likely to interfere with cognition (excluding diagnosis for patients)
Affiliated with a social security scheme
Having received oral and written information about the protocol and having signed a consent form to participate in this research.
DCS+ group:
\- Meeting the diagnostic criteria for "subjective cognitive decline-plus" (Jessen criteria (Jessen et al., 2014).
Alzheimer's patients "Mild Cognitive Impairment due to Alzheimer's Disease," "MCI-MA":
\- Meeting the diagnostic criteria for "Mild neurocognitive disorder due to Alzheimer's disease" (criteria of (Albert et al., 2011))
De novo" Parkinsonian patients, "MPdn":
\- Presenting with newly diagnosed ("de novo") Parkinson's disease and free of cognitive deficits (criteria of Postuma et al., 2015 (Postuma et al., 2015))
Parkinsonian patients with "Mild Cognitive Impairment, "MCI-MP":
\- Presenting Parkinson's disease associated with "mild neurocognitive impairment" (criteria of Litvan et al., 2012 (Litvan et al., 2012))

Exclusion Criteria18

All participants (healthy volunteers and patients)
Contraindications to MRI :
Abdominal circumference + upper limbs sticking to the body \> 200 cm;
Implantable pacemaker or defibrillator;
Neurosurgical clips;
Cochlear implants ;
Neural or peripheral stimulator;
Intra-orbital or encephalic metallic foreign bodies;
Endoprostheses fitted less than 4 weeks ago and osteosynthesis devices fitted less than 6 weeks ago;
Claustrophobia.
Pregnant or breast-feeding women;
Adults under legal protection (safeguard of justice, curatorship, guardianship), persons deprived of liberty.
Patients only
Score \>2 on the modified Hachinski scale (Hachinski et al., 2012)
Dementia according to McKhann criteria (McKhann et al., 2011)
Sensory deficit interfering with experimental tests
Healthy volunteers only
\- Cognitive impairment (MoCA score \< 26)

Interventions

DIAGNOSTIC_TESTfMRI

functional MRI

DIAGNOSTIC_TESTCONFMEM

The aim of this paradigm is to identify the impact of cognitive conflict situations on recognition memory (the ability to judge whether or not a stimulus has been previously presented).