RecruitingNot ApplicableNCT06080659

Network-based biOmarker Discovery of Neurodegenerative Diseases Using Multimodal Connectivity

Sponsor

Rennes University Hospital

Enrollment

120 participants

Start Date

Nov 6, 2023

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease Alzheimer Disease, Early Onset

Summary

The aim of the NODAL clinical trial is to demonstrate the feasibility of new, low-cost, non-invasive biomarkers of neurodegenerative pathologies as early Alzheimer and Parkinson, based on the estimation of the multimodal connectome.

Eligibility

Min Age: 50 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study investigates how brain connections change in people with neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. Researchers use brain scans and other tests to find biological markers (biomarkers) that may help detect these diseases earlier. **You may be eligible if...** - You are a French native speaker and right-handed - You have a primary school education level or higher - You fall into one of these groups: healthy volunteers, people with subjective cognitive complaints, people with mild cognitive impairment due to Alzheimer's, people with newly diagnosed Parkinson's disease (with or without mild cognitive issues) - You are affiliated with a French social security scheme **You may NOT be eligible if...** - You have a pacemaker, cochlear implant, or other metal implants that are unsafe for MRI - You are claustrophobic - You are pregnant or breastfeeding - You have advanced dementia - You have a sensory problem that would interfere with testing - You are under legal guardianship or deprived of liberty Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTfMRI

functional MRI

DIAGNOSTIC_TESTCONFMEM

The aim of this paradigm is to identify the impact of cognitive conflict situations on recognition memory (the ability to judge whether or not a stimulus has been previously presented).