Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression

This study is investigating whether a single session of exercise or a single dose of ibuprofen (an anti-inflammatory pain reliever) can ease depressive symptoms and reduce inflammation in people with bipolar disorder who are currently experiencing depression. Researchers are using brain imaging and blood tests to understand how each intervention affects the brain and immune system. **You may be eligible if...** - You are between 18 and 55 years old - You have a DSM-5 diagnosis of bipolar disorder - You are currently experiencing a depressive episode - Your depression score is above 11 on the QIDS scale - Your BMI is between 18.5 and 35 - You have been on stable medication for at least 4 weeks (or are not medicated and judged appropriate by a doctor) **You may NOT be eligible if...** - You have another major psychiatric condition such as schizophrenia - You have a history of rapid cycling bipolar disorder - You have a significant medical condition that prevents MRI or exercise - You have a known allergy or intolerance to ibuprofen - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.