University of Iowa Interventional Psychiatry Service Patient Registry
Mark Niciu
1,000 participants
Nov 2, 2020
OBSERVATIONAL
Conditions
Summary
The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation. The investigators will obtain various indicators, or biomarkers, of a depressed individuals' state before, during, and/or after these treatments. Such biomarkers include neurobehavioral testing, neuroimaging, electroencephalography, cognitive testing, vocal recordings, epi/genetic testing, and autonomic nervous system measures (i.e. "fight-or-flight" response). The results obtained from this study may provide novel antidepressant treatment response biomarkers, with the future goal of targeting a given treatment to an individual patient ("personalized medicine").
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
ECT for the treatment of treatment-resistant depression OR Bipolar Disorder in an active major depressive episode
TMS for the treatment of treatment-resistant depression in an active major depressive episode
Intravenous ketamine infusion for the treatment of treatment-resistant depression in an active major depressive episode
Intranasal esketamine insufflation for the treatment of treatment-resistant depression in an active major depressive episode
TMS for the treatment of OCD
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04480918