RecruitingNCT04480918

University of Iowa Interventional Psychiatry Service Patient Registry


Sponsor

Mark Niciu

Enrollment

1,000 participants

Start Date

Nov 2, 2020

Study Type

OBSERVATIONAL

Conditions

Summary

The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation. The investigators will obtain various indicators, or biomarkers, of a depressed individuals' state before, during, and/or after these treatments. Such biomarkers include neurobehavioral testing, neuroimaging, electroencephalography, cognitive testing, vocal recordings, epi/genetic testing, and autonomic nervous system measures (i.e. "fight-or-flight" response). The results obtained from this study may provide novel antidepressant treatment response biomarkers, with the future goal of targeting a given treatment to an individual patient ("personalized medicine").


Eligibility

Min Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This is a patient registry — a long-term data collection study — tracking outcomes for people receiving specialized psychiatric treatments such as transcranial magnetic stimulation (TMS) or ketamine infusions for depression or OCD that has not responded to standard medications. **You may be eligible if...** - You are between 18 and 99 years old - You have been diagnosed with major depressive disorder, bipolar disorder with a current depressive episode, or treatment-resistant OCD - Your condition has not improved enough with standard treatments - You are receiving care from the Interventional Psychiatry Service at the participating institution **You may NOT be eligible if...** - You are under 18 years old - Your primary diagnosis is something other than depression, bipolar disorder, or OCD - You have an unstable serious medical condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEElectroconvulsive Therapy (ECT)

ECT for the treatment of treatment-resistant depression OR Bipolar Disorder in an active major depressive episode

DEVICETranscranial Magnetic Stimulation (TMS)

TMS for the treatment of treatment-resistant depression in an active major depressive episode

DRUGKetamine

Intravenous ketamine infusion for the treatment of treatment-resistant depression in an active major depressive episode

DRUGEsketamine

Intranasal esketamine insufflation for the treatment of treatment-resistant depression in an active major depressive episode

DEVICEDeep Transcranial Magnetic Stimulation (dTMS)

TMS for the treatment of OCD


Locations(1)

University of Iowa Health Care

Iowa City, Iowa, United States

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NCT04480918


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