Neoadjuvant Adebrelimab Plus Etoposide and Cisplatin in Neuroendocrine Bladder Carcinoma

Exclusion Criteria21

• Prior anti-PD-1, anti-PD-L1 or anti-CTLA-4 therapy.
• Prior drug therapy for cancer, except:
• Intravesical chemotherapy or immunotherapy ended at least 1 week before the start of study.
• Prior radiotherapy for bladder cancer.
• Participants allergic to adebrelimab and its components.
• Participants who have received other antitumor therapy or immunomodulatory therapy (including corticosteroid therapy, immunotherapy) or participated in other clinical studies within 4 weeks before the start of study treatment, or have not recovered from previous toxicity (except for 2 degree alopecia and 1 degree neurotoxicity).
• Pregnant or lactating females.
• HIV Positive.
• Participants with active hepatitis B or C:
• For participants with HBsAg or HBcAb positive and detected HBV DNA copy number (quantitative detection limit is 500IU/ml, or reach the positive value of copy number detected by the research center), HBV DNA must be tested for screening in such patients.
• Participants positive for HCV antibodies were enrolled in this study only if the PCR test for HCV RNA was negative.
• Active tuberculosis.
• Active autoimmune disease that requires systemic treatment within the past 2 years (such as disease-modulating drugs, corticosteroids, or immunosuppressive drugs). Replacement therapy (such as thyroxine, insulin, or physiologic corticosteroid replacement therapy for renal or pituitary insufficiency) are accepted.
• Other serious, uncontrolled medical conditions that may affect protocol adherence or interfere with interpretation of results. These include active opportunistic or progressive (severe) infections, uncontrolled diabetes, cardiovascular disease (heart failure as defined by the New York Heart Association scale as grade III or IV, cardiac conduction block above grade II, myocardial infarction within the last 6 months, unstable arrhythmia or unstable angina, cerebral infarction within the last 3 months, etc.), or pulmonary disease (interstitial pneumonia, Obstructive pulmonary disease and a history of symptomatic bronchospasm).
• Those who received live vaccine within 4 weeks prior to the start of treatment (seasonal influenza vaccines are usually inactivated and therefore permitted for use). Intranasal vaccines are live vaccines, so they are not allowed to be used).
• Prior allogeneic hematopoietic stem cell transplantation or solid organ transplantation.
• History of psychotropic substance abuse and cannot abstain or have a history of mental disorders.
• Pleural fluid or ascites associated with clinical symptoms or requiring symptomatic management.
• Participants with other malignancies that have not healed in the past 5 years, excluding apparently cured malignancies, or curable cancers such as basal or squamous cell skin cancer, localized low-risk prostate cancer, cervical carcinoma in situ, or breast carcinoma in situ.
• Concomitant upper tract urothelial carcinoma (pelvis and ureter urothelial carcinoma).
• Other severe, acute, or chronic medical or psychiatric disorders, or laboratory abnormalities that, in the investigator's opinion, may increase the risks associated with study participation or that may interfere with the interpretation of the study results.