RecruitingNCT06092385

SASL Swiss Cirrhosis Cohort

SASL Swiss Cirrhosis Cohort Study

Sponsor

University Hospital, Basel, Switzerland

Enrollment

3,000 participants

Start Date

Jun 4, 2024

Study Type

OBSERVATIONAL

Conditions

Liver Cirrhosis

Summary

This is a national prospective long-term multicentre observational cohort study following patients with cirrhosis in order to systematically and longitudinally record epidemiological, clinical, histological, psychosocial and patient-reported data and biobank biological material from patients with cirrhosis. The central element of all scientific operation and productivity in the Swiss Cirrhosis Cohort Study (SSCiCoS) is the so-called "nested project" (NP). Based on the evolving large pool of data and biological samples, SSCiCoS investigators use the data pool in order to investigate specific hypotheses and questions.

Eligibility

Min Age: 18 Years

Inclusion Criteria2

A) Patients with chronic liver disease and histologically proven cirrhosis
B) Control subjects with no signs of cirrhosis

Exclusion Criteria2

Age <18 years
patients who developed hepatocellular carcinoma (HCC) and/or cholangiocellular carcinoma (CCC)

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Interventions

OTHERData collection

Clinical assessment and blood sampling at day of inclusion and in 6- monthly intervals for stable cirrhotic patients; at day of inclusion and on days 3, 7, 14 and 28 for acute decompensation or acute-on-chronic liver failure patients; assessment of clinical, psychosocial/behavioural and patient-reported data in parallel with blood sampling; * Biobanking of PBMCs and serum/plasma samples * Biobanking of other biological material if sampled for clinical reasons (liver biopsies, ascites, urine, gut mucosa, lymph nodes)