tACS to Enhance Language Abilities
Transcranial Alternating Current Stimulation (tACS) to Enhance Language Abilities
University of Pennsylvania
120 participants
Jul 12, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests. Researchers will compare the post-stroke aphasia group with aged matched controls to see if brain response to tACS differs between groups.
Eligibility
Inclusion Criteria5
- Presence of aphasia
- Suffered a single, left hemisphere stroke
- Stroke ≥6 months old (chronic) at the time of enrollment
- Right-handedness
- Must be able to understand the nature of the study, and give informed consent
Exclusion Criteria20
- Inability to understand the nature of the study
- Marked naming impairment
- Impaired non-verbal, conceptual processing
- History of significant medical or neurological disorder (other than stroke)
- History of significant or poorly controlled psychiatric disorders
- Current abuse of alcohol or drugs, prescription or otherwise
- Nursing a child, pregnancy, or intent to become pregnant during the study
- Clinically significant hearing loss
- Contraindications to tACS
- Contraindications to MRI
- Diagnosis of a neurodegenerative disease or clinically significant cognitive complaint
- Any unrelated neurologic or physical condition that impairs communication ability
- History of unrelated neurological conditions including but not limited to traumatic brain injury, stroke, or small vessel disease that has resulted in a neurologic deficit
- Any additional neurological condition that would likely reduce the safety of study participation, including central nervous system (CNS) vasculitis, intracranial tumor, intracranial aneurysm, multiple sclerosis or arteriovenous malformations
- A medically unstable cardiopulmonary or metabolic disorder
- Terminal illness associated with survival \<12 months
- Major active psychiatric illness that may interfere with required study procedures or treatments as determined by the enrolling physician
- Current abuse of alcohol or drugs, prescription or otherwise
- Contraindications to tACS
- Contraindications to MRI
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Transcranial Alternating Current Stimulation (tACS) is a device that applies a low-intensity electrical current to the brain through electrodes on the scalp.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06092814