Reduced-dose RT With/Without CCT Versus Standard CCRT for High-risk LANPC Who Achieved CR Post Induction Chemotherapy

This study is investigating whether patients with locally advanced nasopharyngeal carcinoma (cancer at the back of the nasal cavity) who respond exceptionally well to initial chemotherapy and immunotherapy can be treated with a lower dose of radiation — either with or without additional chemotherapy — compared to the standard, higher-dose treatment. **You may be eligible if...** - You have been diagnosed with nasopharyngeal carcinoma (a specific type of throat/nasal cancer) - Your cancer is stage III or IVA - After 3 cycles of platinum-based chemotherapy plus immunotherapy, imaging, biopsy, and a blood test (EBV DNA) all confirm complete remission - You are in reasonably good health (ECOG 0-1) - Your blood counts, liver, and kidney function are adequate **You may NOT be eligible if...** - You did not achieve complete remission after initial treatment - You have serious infection, autoimmune disease, or other major illnesses - You have had prior radiation to the head and neck area - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.