RecruitingNot ApplicableNCT06094192

Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation

Personalized Synchronization of Cortical Rhythms to Improve Memory in Alzheimer's Disease


Sponsor

Boston University Charles River Campus

Enrollment

204 participants

Start Date

Dec 20, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The investigators will evaluate the theory that Alzheimer's disease-related memory impairment derives from the inefficient orchestration of rhythmic activity at the level of large-scale cortical networks. The results as expected to elucidate AD-related pathophysiology and set groundwork for the development of drug-free interventions for improving memory in AD and related dementias.


Eligibility

Min Age: 50 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a non-invasive brain stimulation technique can improve memory in people with mild Alzheimer's disease. The technology uses gentle magnetic pulses applied to the outside of the head — no surgery required — to try to activate areas of the brain involved in memory. **You may be eligible if...** - You are between 50 and 100 years old - You have been diagnosed with mild Alzheimer's disease dementia (meeting NIA-AA criteria) - Your cognitive test score (MoCA) is between 10–25 - Your memory and at least one other thinking ability are significantly worse than expected for your age and education level **You may NOT be eligible if...** - You have a pacemaker, metal implants in your head, or other devices that make brain stimulation unsafe - You have severe dementia - You have another condition causing your cognitive decline (such as stroke or another type of dementia) - You are unable or unwilling to attend regular study sessions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEHigh definition transcranial electrical current stimulation

Low-intensity and safe, noninvasive application of electrical current to the human scalp with the goal of gradually modulating levels of neuronal excitability.


Locations(1)

677 Beacon St. Room 308

Boston, Massachusetts, United States

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NCT06094192


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