RecruitingNot ApplicableNCT06095063

dTMS for Subjective Cognitive Decline

Effect of Deep Transcranial Magnetic Stimulation (dTMS) on Cognition in Older Adults With Subjective Cognitive Decline (SCD)


Sponsor

Rotman Research Institute at Baycrest

Enrollment

30 participants

Start Date

Nov 15, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Deep transcranial magnetic stimulation (dTMS) is a brain stimulation technique that involves generating a brief magnetic field in a coil that is placed on the scalp. The magnetic field passes through the skull and induces a weak electrical current in the brain that briefly activates neural circuits at the stimulation site. The Brainsway dTMS H7-Coil is able to target an area of the brain that has been shown in studies to be linked to greater resilience to cognitive decline. In this study, the investigators will combine dTMS with cognitive training in older adults with subjective cognitive decline (SCD) and examine the effect of this treatment on memory, other cognitive abilities, and mood. In addition, the investigators will examine the combined effects of dTMS and cognitive training on brain activity as measured using electroencephalography (EEG). Approximately 30 older adults from ages 55 to 70 with SCD and a positive family history of Alzheimer's disease will be enrolled in this study.


Eligibility

Min Age: 55 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a brain stimulation technique called deep transcranial magnetic stimulation (dTMS) in people who have a family history of Alzheimer's disease and are experiencing subjective memory concerns — meaning they notice their memory is not as sharp, even if tests still appear normal. The goal is to see if early intervention can slow or prevent cognitive decline. **You may be eligible if...** - You have a first-degree relative (parent or sibling) who had Alzheimer's disease - You have concerns about your own memory - Your cognitive test score (MoCA) is 26 or higher (normal range) - You have been on stable medications for at least 2 months - You have a close friend or family member who can complete questionnaires about you **You may NOT be eligible if...** - You have a metal plate in your head (dental implants are generally fine) - You have a pacemaker or other implanted electrical device - You have a history of seizures - You have been diagnosed with dementia or another significant neurological condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEActive Brainsway H7-Coil Deep TMS System

Deep Transcranial Magnetic Stimulation (dTMS) is a new form of TMS which allows direct stimulation of deeper neuronal pathways than the standard TMS. The H-coil is a novel dTMS coil designed to allow deeper brain stimulation without a significant increase of electric fields induced in superficial cortical regions. dTMS will be administered daily for 4 consecutive weeks.

DEVICESham Brainsway H7-Coil Deep TMS System

In addition to the active H-coil, a sham coil is included in the system. The active and sham coils are connected to a control switch, which alternates between real and sham operation modes. The sham treatment will be administered daily for 4 consecutive weeks.

OTHERCognitive Training

Cognitive training will be conducted using the BrainHQ software program.


Locations(1)

Rotman Research Institute at Baycrest

Toronto, Ontario, Canada

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NCT06095063


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