Adipose Tissue Blood Flow in Aging Humans
Mayo Clinic
24 participants
Feb 15, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this basic science clinical trial is to understand whether adipose tissue blood flow changes between younger and older healthy adults. The main question\[s\] it aims to answer are: * Is basal and nutrient responsive adipose tissue blood flow (ATBF) different between younger and older adults * What molecular and systemic signatures related to adipose tissue blood flow are altered between these two groups. Participants will undergo measurements of adipose tissue blood flow using the xenon washout technique, undergo 2 abdominal subcutaneous adipose tissue biopsies, and drink a sugary drink.
Eligibility
Inclusion Criteria2
- Within the ages of 18-35 years or 65-80 years at time of study visit
- BMI between 20-25.0 kg/m2.
Exclusion Criteria6
- Presence of diagnosed cardiometabolic diseases (e.g., Type 2 diabetes, hypertension, Heart Failure)
- Taking prescription anticoagulants
- Taking prescriptions or supplements that effect adipose tissue metabolism (i.e., statins, Thiazolidinediones, niacin, atypical antipsychotics, or fish oil)
- Pregnant or nursing
- Inability to provide written informed consent
- Smokers
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Interventions
Consumption of 75 gm oral glucose load in order to test nutrient responsiveness
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06096532