RecruitingNCT06098300

Effects of Change in Blood Pressure on Retinal Capillary Rarefaction in Patients With Arterial Hypertension

Effects of Change in Blood Pressure on Retinal Capillary Rarefaction in Patients With Arterial Hypertension - a Pilot Study

Sponsor

Medical University of Vienna

Enrollment

30 participants

Start Date

Sep 1, 2023

Study Type

OBSERVATIONAL

Conditions

Blood Pressure, High Arterial Hypertension

Summary

To evaluate whether in patients with initially poorly-controlled arterial hypertension, structural and functional differences in the retina and choroid remain after achieving a well-controlled blood pressure.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Inclusion Criteria7

Men and Women aged ≥ 18 years
Signed informed consent
Apart from hypertensive retinopathy, normal ophthalmic findings
Non-Smokers
Patients with initially diagnosed or pre-existing mild to moderate primary arterial hypertension (systolic office blood pressure ≥ 140 mmHg and/or diastolic office blood pressure ≥ 90 mmHg)
Planned initiation of antihypertensive medication or planned adaption of antihypertensive medication by the Department of Cardiology
Subject agrees to perform regular blood pressure self-measurements and to document blood pressure values in a diary

Exclusion Criteria9

Participation in a clinical trial in the three weeks preceding the study
Blood donation in the three weeks preceding the study
Symptoms of a clinically relevant illness in the three weeks preceding the study
History of family history of epilepsy
Secondary hypertension (e.g.: hyperaldosteronism, pheochromocytoma, renal artery stenosis, renal parenchymal diseases, Cushing-syndrome, Coarctatio aortae)
History of hypertensive encephalopathy or intracerebral bleeding
Diabetes mellitus Type 1 or Type 2
Pregnant or breast-feeding women
Women of childbearing potential (neither menopausal, nor hysterectomized, nor sterilized) not using effective contraception