Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients
Effect of Nitrate Supplementation on Blood Pressure and Systemic Microvascular Function of Resistant Hypertensive Patients
National Institute of Cardiology, Laranjeiras, Brazil
50 participants
Nov 1, 2023
INTERVENTIONAL
Conditions
Summary
Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity. High blood pressure (BP) levels increase the chances of coronary artery disease (CAD), heart failure (HF), stroke, chronic renal failure (CRF) and death. Beetroot powder may be an easier way to increase the availability of nitric oxide and consequently vasodilation in these patients. However, studies are needed to evaluate its benefits in patients with AH.
Eligibility
Inclusion Criteria1
- Resistant hypertension, with a diagnosis described in the medical record, without changing medications or increasing doses in the last 30 days.
Exclusion Criteria4
- neoplasms
- heart failure
- use of medications with nitrate in their formula
- patients undergoing renal denervation
Interventions
Beetroot extract powder supplementation with 400mg of nitrate per dose in the amount of 10g per day orally will be used in the group.
The placebo will be administered as a colored and flavored isocaloric supplement composed of maltodextrin.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06169241