RecruitingEarly Phase 1NCT06169241

Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients

Effect of Nitrate Supplementation on Blood Pressure and Systemic Microvascular Function of Resistant Hypertensive Patients


Sponsor

National Institute of Cardiology, Laranjeiras, Brazil

Enrollment

50 participants

Start Date

Nov 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity. High blood pressure (BP) levels increase the chances of coronary artery disease (CAD), heart failure (HF), stroke, chronic renal failure (CRF) and death. Beetroot powder may be an easier way to increase the availability of nitric oxide and consequently vasodilation in these patients. However, studies are needed to evaluate its benefits in patients with AH.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether nitrate supplements (like those found in beetroot juice) can help lower blood pressure and improve blood vessel function in people with resistant hypertension — high blood pressure that does not respond well to three or more medications. **You may be eligible if...** - You have resistant hypertension (high blood pressure that has not responded to multiple medications) - Your medications have not been changed or increased in the last 30 days **You may NOT be eligible if...** - You have been diagnosed with cancer - You have heart failure - You are already taking any nitrate-containing medications - You have undergone a renal denervation procedure (a nerve-blocking treatment for blood pressure) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTBeetroot extract

Beetroot extract powder supplementation with 400mg of nitrate per dose in the amount of 10g per day orally will be used in the group.

DIETARY_SUPPLEMENTPlacebo

The placebo will be administered as a colored and flavored isocaloric supplement composed of maltodextrin.


Locations(1)

National Institute of Cardiology

Rio de Janeiro, Brazil

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NCT06169241


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