RecruitingPhase 1NCT06100822

Managing Chronic Tendon Pain by Metformin

Managing Chronic Tendon Pain by Repurposing Metformin


Sponsor

James Wang

Enrollment

40 participants

Start Date

May 24, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of the current exploratory clinical trial is to determine the effect of oral ingestion of metformin (OIM) in non-diabetic patients with chronic Achilles tendon pain. The trial has two aims; 1) to assess the effects of OIM treatment on tendon pain, and 2) to determine the effects of OIM capsules on tendon healing and repair. Twenty participants will be treated with metformin capsules for 16 weeks combined with a home exercise program. A comparison group of 20 participants will be treated with placebo tablets along with home exercise program.


Eligibility

Min Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Metformin and a drug called Placebo for people with achilles tendinopathy, chronic pain, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 50 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMetformin

500 mg capsules of Metformin Extended Release

DRUGPlacebo

500 mg capsules of placebo pills


Locations(1)

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

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NCT06100822


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