Biological Sex and CTEPH-related RV Dysfunction and Recovery (BIOSPHeRe)

This study (BIOSPHeRe) is investigating whether biological sex affects how the right side of the heart (right ventricle) is damaged and how well it recovers in people with a condition called chronic thromboembolic pulmonary hypertension (CTEPH) — high blood pressure in the lungs caused by old blood clots that never fully dissolved. **You may be eligible if...** - You are 18 or older - You have been diagnosed with CTEPH according to current guidelines - You have had a heart ultrasound (echocardiogram) and a right heart catheterization (a procedure to measure pressure in the lungs) at the time of diagnosis - If participating in the surgery arm: you underwent pulmonary thromboendarterectomy (PTE) surgery and had a follow-up heart ultrasound 3–9 months after surgery **You may NOT be eligible if...** - Your pulmonary hypertension diagnosis is unclear or mixed - You are under 18 - You were diagnosed with CTEPH during pregnancy - You did not have both an echocardiogram and right heart catheterization at diagnosis Talk to your doctor to see if this trial is right for you.