Mechanistic Insights From Bronchoscopy Airway Samples

This research study is collecting bronchoscopy (lung airway) samples to better understand the biological mechanisms behind asthma. It compares samples from people with asthma to those from healthy individuals, aiming to identify what makes asthmatic airways different at a cellular and molecular level. **You may be eligible if...** - You are 18–70 years old - You are either a healthy person with no allergies or airway reactivity, OR you have a diagnosed history of asthma with confirmed airway reactivity - Asthmatics must not have used corticosteroids (oral or inhaled) in the past 6 weeks **You may NOT be eligible if...** - You currently smoke or have smoked more than 10 pack-years total - You are pregnant or breastfeeding - You have any lung disease other than asthma - You have had prior esophageal or hernia surgery - You are currently taking prohibited medications (certain antihistamines, steroids, or asthma drugs not washed out in time) - You are enrolled in another drug trial Talk to your doctor to see if this trial is right for you.