Biennial CEM in Women With a Personal History of Breast Cancer

This trial is comparing contrast-enhanced mammography (CEM) to standard 3D mammography (tomosynthesis) in women who have previously had breast cancer, to see whether CEM catches more cancers and reduces unnecessary procedures. **You may be eligible if...** - You are a woman aged 30–79 with a personal history of breast cancer - It has been at least one year since your last breast surgery or treatment - You are scheduled for a routine annual mammogram - You have not had a screening breast MRI within the past 24 months **You may NOT be eligible if...** - You have a history of moderate or severe iodinated contrast reaction (mild reactions may be manageable with premedication) - You have breast implants in the breasts to be screened - You have had a bilateral mastectomy - Your kidney function is significantly reduced (eGFR below 45) or you have only one kidney - You are pregnant or breastfeeding - You are currently receiving chemotherapy for any cancer - You have stage 4 cancer with spread to organs or brain - You have had a CEM exam within the prior 23 months Talk to your doctor to see if this trial is right for you.