REDucing Hot FLASHes in Women Using Endocrine Therapy.

The REDFLASH trial is testing medications to reduce hot flashes in women who are taking hormone-blocking therapy (endocrine therapy like tamoxifen or aromatase inhibitors) for breast cancer treatment. Hot flashes are a very common and disruptive side effect of these medications. **You may be eligible if...** - You are a woman (pre-, peri-, or postmenopausal), 18 or older - You are taking tamoxifen, an aromatase inhibitor, or a hormone-suppressing injection (LHRH analogue) for at least 4 weeks and plan to continue - You are having at least 14 hot flashes per week, for at least 1 month, and want to start treatment for them **You may NOT be eligible if...** - You are pregnant or breastfeeding - You are receiving chemotherapy or immunotherapy currently or recently (within 8 weeks) - You use antidepressants (including venlafaxine or St. John's Wort) within the past year - You have severely reduced kidney function or liver cirrhosis - You currently take gabapentin, calcium channel blockers, oxybutynin, or other hot flash treatments - Your cancer is being treated in a palliative (non-curative) setting Talk to your doctor to see if this trial is right for you.