Neoadjuvant Chemotherapy for Obstructive Colon cancER First Treated by cOlostomy

This study tests whether giving chemotherapy before surgery (neoadjuvant chemotherapy) to patients with a bowel-blocking colon cancer — who already had a temporary colostomy placed to relieve the blockage — leads to better outcomes than going straight to surgery. **You may be eligible if...** - You are 18 or older with a confirmed colon cancer (not rectal) causing a blockage that was treated with a temporary colostomy - Your cancer has not spread to other organs (no metastases) - Your cancer is a specific type (MSS/pMMR adenocarcinoma) - You have not had prior chemotherapy or pelvic radiation - Your blood counts and organ function are within acceptable ranges **You may NOT be eligible if...** - Your cancer has spread to the liver, lungs, or lining of the abdomen - You have a rectal cancer (within 10 cm of the anus) - You have inflammatory bowel disease, a hereditary colon cancer syndrome, or recent heart problems - You are pregnant or breastfeeding - You have nerve damage (peripheral neuropathy) Talk to your doctor to see if this trial is right for you.