Esketamine Combined With Remimazolam on Postoperative Sleep Disturbance and Anxiety in Patients

This study looks at whether using a combination of esketamine and remimazolam (both anesthesia-related medications) during or after elective surgery helps reduce sleep problems and anxiety that patients sometimes experience after an operation. **You may be eligible if...** - You are between 20 and 65 years old - You are scheduled for elective (non-emergency) surgery - You have a BMI between 19 and 30 - You are in generally good to moderate health (ASA class I–III) **You may NOT be eligible if...** - You have a history of neurological disease, chronic pain, or long-term opioid use - You have heart disease, severe high blood pressure, asthma, or significant liver/kidney problems - You have a history of gastrointestinal disease (like Crohn's or peptic ulcer) - You are pregnant or breastfeeding - You are allergic to anesthesia medications, opioids, or NSAIDs - You participated in another drug trial in the past 4 weeks Talk to your doctor to see if this trial is right for you.