Neuromodulation of Different Doses to Treat TRD Guided by pBFS Technique

This study tests whether different doses of repetitive transcranial magnetic stimulation (rTMS — a non-invasive brain stimulation technique), guided by personalized brain mapping (pBFS), work better to treat treatment-resistant depression (depression that hasn't responded to multiple antidepressants). **You may be eligible if...** - You are between 18 and 65 years old with a confirmed diagnosis of major depression without psychotic symptoms - Your depression is currently severe (HAMD-17 score ≥ 20 and MADRS ≥ 20) - Your depression has not responded to at least two adequate antidepressant trials (moderate treatment resistance) - You have been on a stable antidepressant regimen (SSRIs or SNRIs) for at least 4 weeks **You may NOT be eligible if...** - You have a pacemaker, cochlear implant, or metal in your body, or claustrophobia - You have epilepsy or a history of seizures in the last 12 months - You have schizophrenia, bipolar disorder, or other serious psychiatric conditions - You have received ECT, prior rTMS, or other brain stimulation treatments in the last 3 months - You are pregnant or breastfeeding, or planning to become pregnant during the study Talk to your doctor to see if this trial is right for you.