Remimazolam vs. Propofol: Impact on Postoperative Delirium in Neurosurgical Patients
Effect of Remimazolam Versus Propofol Anesthesia on Postoperative Delirium in Neurosurgical Patients: A Randomised, Controlled, Noninferiority Trial
Samsung Medical Center
696 participants
Jan 29, 2024
INTERVENTIONAL
Conditions
Summary
The investigator aimed to evaluate the incidence of postoperative delirium after remimazolam-based total intravenous anestheisa (TIVA) compared to the propofol-based TIVA in patients undergoing neurosurgery.
Eligibility
Inclusion Criteria1
- American society of anesthesia (ASA) class I - III
Exclusion Criteria5
- Severe respiratory, cardiovascular, or hepatic disease (child-pugh C)
- Dependency on psychiatric drugs or alcohol
- Severe sensory impairments that impede communication
- Preoprative delirium
- Hypersensitivity, allergies, or contraindication to the study drugs.
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Interventions
General anesthesia will be induced and maintained using continuous infusion of intravenous remimazolam.
General anesthesia will be induced and maintained using target-controlled infusion of intravenous propofol.
Locations(1)
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NCT06115031