Postoperative Delirium Clinical Trials

56 recruitingLast updated: June 18, 2026

There are 56 actively recruiting postoperative delirium clinical trials across 17 countries. Studies span Not Applicable, Phase 3, Phase 4, Phase 2. Top locations include Beijing, Beijing Municipality, China, Beijing, China, Zhengzhou, Henan, China. Updated daily from ClinicalTrials.gov.


Postoperative Delirium Trials at a Glance

56 actively recruiting trials for postoperative delirium are listed on ClinicalTrialsFinder across 6 cities in 17 countries. The largest study group is Not Applicable with 20 trials, with the heaviest enrollment activity in Beijing, Beijing, and Zhengzhou. Lead sponsors running postoperative delirium studies include Beijing Tiantan Hospital, Charite University, Berlin, Germany, and Xijing Hospital.

Browse postoperative delirium trials by phase

Treatments under study

About Postoperative Delirium Clinical Trials

Looking for clinical trials for Postoperative Delirium? There are currently 44 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Postoperative Delirium trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Postoperative Delirium clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 56 trials

Recruiting
Not Applicable

Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival

Intraoperative hypothermiaCancer SurgeryPostoperative Delirium+2 more
Peking University First Hospital3,992 enrolled36 locationsNCT06256354
Recruiting

Preoperative Distress and Postoperative Delirium in Elderly Patients Undergoing Major Orthopedic Surgery

Postoperative Delirium
Elazıg Fethi Sekin Sehir Hastanesi150 enrolled1 locationNCT07512752
Recruiting

The Effects of Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy

Postoperative Neurocognitive DisorderCognitive FunctionsTotal Intravenous Anesthesia+6 more
Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital60 enrolled1 locationNCT07637357
Recruiting

PROSEVO Trial (Propofol-Sevoflurane Delirium Target Trial Emulation)

Postoperative Delirium
Charite University, Berlin, Germany100,000 enrolled2 locationsNCT07612579
Recruiting
Phase 3

Ketofol Versus Ketodex for POD Prophylaxis in Elderly Cancer Surgery

Postoperative Delirium (POD)
Cairo University180 enrolled1 locationNCT07627906
Recruiting

Sex-Dependent Risk of Postoperative Delirium and Mediating Effects of Family Visits

Postoperative Delirium (POD)Sex Differences
Julian Rössler471 enrolled1 locationNCT07502391
Recruiting

Naples Prognostic Score for Predicting Postoperative Delirium

Postoperative Delirium
South Valley University168 enrolled1 locationNCT07297017
Recruiting
Not Applicable

Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients

Postoperative Neurocognitive DisorderInsomniaPostoperative Delirium+1 more
Massachusetts General Hospital50 enrolled1 locationNCT06375265
Recruiting
Not Applicable

PARO-agitation-study

Postoperative PainAgitationAnxiety After Surgery+1 more
Hannover Medical School300 enrolled1 locationNCT07568093
Recruiting
Phase 4

Effects of Ciprofol on Postoperative Delirium and Outcomes in Elderly Patients Undergoing Major Thoracic Surgery

Postoperative Delirium (POD)
Wang Tianlong214 enrolled9 locationsNCT06674226
Recruiting

Incidence of Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery

Postoperative Delirium
Sir Ganga Ram Hospital270 enrolled2 locationsNCT04707794
Recruiting
Not Applicable

Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial

DiabetesPostoperative Delirium (POD)
Xijing Hospital450 enrolled1 locationNCT06788743
Recruiting

Elderly Patients Undergoing Surgery During Perioperative Period

ElderlyPostoperative ComplicationsPostoperative Delirium (POD)+2 more
Second Affiliated Hospital of Wenzhou Medical University1,200 enrolled1 locationNCT07314762
Recruiting
Not Applicable

Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery

Postoperative PainPostoperative Delirium (POD)Burst Suppression+2 more
Istanbul University - Cerrahpasa70 enrolled2 locationsNCT07357480
Recruiting

Inflammatory Biomarkers and Postoperative Delirium in Pediatric Circumcision

Postoperative DeliriumPediatric AnesthesiaInflammatory Biomarkers
Ankara Etlik City Hospital140 enrolled1 locationNCT07323485
Recruiting
Not Applicable

Increasing Preoperative Cognitive Reserve to Prevent Postoperative Cognitive Dysfunction in Cardiac Surgical Patients

Postoperative DeliriumPostoperative Cognitive DeclinePostoperative Cognitive Dysfunction
Heart and Brain Research Group, Germany100 enrolled1 locationNCT04493996
Recruiting
Not Applicable

Decreasing Preoperative Stress to Prevent Postoperative Delirium and Postoperative Cognitive Decline in Cardiac Surgical Patients.

Postoperative DeliriumPostoperative Cognitive DysfunctionPreoperative Stress
Heart and Brain Research Group, Germany125 enrolled1 locationNCT05036538
Recruiting
Not Applicable

Dexmedetomidine vs Midazolam in Coronary Artery By-pass Surgery

Postoperative Delirium
Cumhuriyet University60 enrolled1 locationNCT07411794
Recruiting

Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery

Postoperative DeliriumPostoperative Cognitive DysfunctionPostoperative Stroke
University Hospital, Basel, Switzerland500 enrolled4 locationsNCT05595954
Recruiting

Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery

Acute Kidney InjuryPostoperative Delirium (POD)Cardiac Surgery+2 more
Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital230 enrolled1 locationNCT07324694