RecruitingNCT06115122

PEPPI Study: Identification of Women at Risk for Placental Dysfunction

PEPPI Study: Identification of Women at Risk for Placental Dysfunction During the First and Third Trimesters of Pregnancy


Sponsor

Oulu University Hospital

Enrollment

3,000 participants

Start Date

Feb 15, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a Finnish general population. Condition or disease: pre-eclampsia, intrauterine growth restriction, polycystic ovary syndrome


Eligibility

Plain Language Summary

Simplified for easier understanding

This Finnish study (PEPPI) aims to identify pregnant women who are at risk for placental dysfunction — when the placenta doesn't work properly — which can cause pregnancy complications like pre-eclampsia or poor fetal growth. Blood samples in early and late pregnancy will be used to find early warning markers. **You may be eligible if:** - You are pregnant and in your first trimester - You are 18 or older - You understand Finnish - You consent to blood sampling in the first trimester - For the extended study (FERPPI): you also consent to third-trimester blood samples and cord blood collection at birth **You may NOT be eligible if:** - You are carrying multiple babies (twins or more) - Your pregnancy ends in miscarriage or termination - You are not able to have blood samples taken in the first trimester Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERPre-eclampsia screening program

Pregnant women will be devided into risk-, control- and PCOS groups according to first trimester screening program.


Locations(1)

The Wellbeing Services County of North Ostrobothnia

Oulu, Finland

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NCT06115122


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