PEPPI Study: Identification of Women at Risk for Placental Dysfunction
PEPPI Study: Identification of Women at Risk for Placental Dysfunction During the First and Third Trimesters of Pregnancy
Oulu University Hospital
3,000 participants
Feb 15, 2022
OBSERVATIONAL
Conditions
Summary
The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a Finnish general population. Condition or disease: pre-eclampsia, intrauterine growth restriction, polycystic ovary syndrome
Eligibility
Inclusion Criteria16
- Mothers
- Pregnant (first trimester)
- Understands Finnish
- ≥18 years
- Signed informed consent
- Participates in PEPPI-study (criteria above)
- Blood samples at first and third trimester of pregnancy
- Permits blood sampling from the umbilical cord when the baby is born
- Biological father to the child born for the mother who participated in PEPPI study
- ≥18 years
- Signed informed consent
- Born to mother who participated in PEPPI study
- Signed informed consent from parent(s)
- Signed informed consent from parent(s)
- Mother has blood samples taken at first and third trimester (iron status)
- Child has blood samples taken at birth and at 3 months of age
Exclusion Criteria13
- Multiple pregnancy
- Miscarriage/termination of the index pregnancy
- No first trimester blood sampling
- No first or third trimester blood sampling
- No umbilical cord blood sample after baby is born
- Fathers
- • Does not understand Finnish
- Children
- • No consent from parent(s)
- • Mother/father declines participation
- No consent from parent(s)
- No blood samples from mother
- No blood samples from child
Interventions
Pregnant women will be devided into risk-, control- and PCOS groups according to first trimester screening program.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06115122