Endothelial Damage in Major Spine Surgery, Measured by Circulating Syndecan-1: an Observational Study.(GlycOrtho)
Endothelial Glycocalyx Damage in Major Spine Surgery, as Measured by Circulating Syndecan-1 Levels: a Prospective Observational Pilot Study.(GlycOrtho)
Istituto Ortopedico Rizzoli
30 participants
Feb 28, 2022
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to learn about endothelial damage in major spine surgery, expressed as rise in circulating Syndecan-1. The main questions it aims to answer are: * What is the extent of endothelial glycocalyx shedding in major spine surgery? * Are there differences in different type of surgical populations? (adolescent idiopathic scoliosis, adult degenerative spine disease, oncologic surgery) To do so, blood samples will be drawn from participants at the following timepoints: * basal * after surgery * if transfusion of Fresh Frozen Plasma: before and after transfusion * Post-Operative Day 1-2-4
Eligibility
Inclusion Criteria4
- Undergoing Major Spine Surgery with estimated blood loss\> 25% of total blood volume
- American Society of Anesthesiology status 1-2-3
- Able to comprehend and sign informed consent.
- If age \<18 years: parent or legal representative able to comprehend and sign informed consent
Exclusion Criteria2
- Surgery outside of laboratory opening hours
- Patients undergoing spine surgery for genetic syndromes/neuromuscular scoliosis
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06119542