The Swedish BioFINDER - Preclinical AD Study

This study, called the Swedish BioFINDER Preclinical AD Study, is tracking people who have early biological signs of Alzheimer's disease in the brain but have not yet developed significant memory problems. Researchers hope to understand how and when Alzheimer's develops before symptoms appear. **You may be eligible if...** - You are 50–80 years old - You have normal or near-normal memory and thinking - If you are 50–60, you must have at least one risk factor: carrying the APOE-E4 gene, a first-degree family member with early dementia, or prior evidence of amyloid plaques in the brain - You speak and understand Swedish without an interpreter **You may NOT be eligible if...** - You already have mild cognitive impairment or dementia - You have a significant brain injury or neurological disease - You have had major depression, bipolar disorder, or psychosis within the past year - You have had alcohol or substance dependence in the past year - You are unwilling or unable to complete brain scans (MRI, PET), blood tests, or cognitive assessments Talk to your doctor to see if this trial is right for you.