RecruitingNot ApplicableNCT06122220

Optic Nerve Sheath Measurement and Angiogenic Factors in Patients With Pre-eclampsia.

Optic Nerve Sheath Measurement and Angiogenic Factors for the Diagnosis of Pre-eclampsia


Sponsor

Saint Thomas Hospital, Panama

Enrollment

200 participants

Start Date

Aug 15, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries. The only cure for THE is termination of pregnancy, which ends up being a decision in which gestational age and maternal risks must be balanced. Angiogenic factors have come to occupy an indispensable place in the arsenal of tools that can be used to separate the patient with a high likelihood of complications from those in whom prolongation of pregnancy could represent an important neonatal benefit. Refining the diagnostic capability of this test would further improve maternal-fetal outcomes and the use of optic nerve sheath diameter (ONSD) measurement could make the difference. The purpose of the present study is to correlate the measurement of ONSD with serum angiogenic factor (AF) values in patients with pre-eclampsia and to determine its predictive ability for adverse perinatal outcomes.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study examines whether measuring the width of the optic nerve sheath (the tissue around the nerve behind the eye) using ultrasound, combined with certain proteins in the blood, can help identify pregnant women who are at risk of dangerously high blood pressure (pre-eclampsia) progressing to a severe state. **You may be eligible if...** - You are pregnant and between 24 and 40 weeks of gestation - You have been diagnosed with pre-eclampsia (high blood pressure during pregnancy) **You may NOT be eligible if...** - You are carrying more than one baby (twins, triplets, etc.) - You have a connective tissue or vascular condition (vasculitis) - You have had 3 or more previous cesarean sections - You have a brain or eye tumor - You have a neurological condition, chronic kidney disease, purpura (a blood disorder), or heart disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREONSD+AF

Measurement of the optic nerve sheath diameter and of sFLT-1/PGIF index


Locations(1)

Saint Thomas Hospital

Panama City, Provincia de Panamá, Panama

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NCT06122220


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