Optimization of Treatment Strategy for Unresectable cN3 Esophageal Squamous Cell Carcinoma

This study is looking for the best treatment approach for people with esophageal squamous cell cancer (a type of cancer in the food pipe) that has spread to many nearby lymph nodes (called cN3 disease) and cannot be removed with surgery. It compares different combinations of chemotherapy, radiation, and immunotherapy. **You may be eligible if...** - You have confirmed squamous cell esophageal cancer - Your cancer has spread to many nearby lymph nodes but not to distant organs (any T, N3, M0) - You have not had prior chest radiation or chemotherapy for this cancer - You are in reasonable overall health (ECOG 0–2) with a life expectancy of at least 6 months **You may NOT be eligible if...** - Your cancer has spread to distant organs - You have a history of other active cancers (except treated skin cancers) - You have active HIV, active hepatitis B or C, or syphilis - You are pregnant or breastfeeding - You have severe heart disease or respiratory failure Talk to your doctor to see if this trial is right for you.