Catheter Ablation in Atrial Fibrillation Patients With HFpEF (STABLE-SR IV Trial)

This trial (STABLE-SR IV) is testing whether a procedure called catheter ablation — which uses radiofrequency energy to correct abnormal heart rhythms — improves outcomes in patients who have both atrial fibrillation (an irregular heartbeat) and a type of heart failure called HFpEF (heart failure with preserved ejection fraction). **You may be eligible if:** - You have symptomatic atrial fibrillation (paroxysmal or persistent) - You have been diagnosed with HFpEF, including symptoms like shortness of breath and evidence of abnormal heart filling on echocardiogram - Your heart pumps normally (ejection fraction at least 50%) - You have elevated heart-strain markers (NT-proBNP above certain thresholds) **You may NOT be eligible if:** - You have a life expectancy under 2 years from a non-cardiac cause - Your atrial fibrillation is caused by a reversible condition like thyroid disease - You have had prior ablation for atrial fibrillation - Your left atrium is significantly enlarged (55 mm or more) - You have had a heart attack, stroke, or cardiac surgery within the past 12 weeks - Your body mass index (BMI) is above 50 - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.