RecruitingNot ApplicableNCT06127056

Intervention Effect of High-Definition Transcranial Alternating Current Stimulation (HD-tACS) on Non-suicidal Self-injury (NSSI)

Sponsor

Anhui Medical University

Enrollment

40 participants

Start Date

May 1, 2023

Study Type

INTERVENTIONAL

Conditions

Transcranial Alternating Current Stimulation Non Suicidal Self Injury

Summary

To investigate the intervention effect of high-definition transcranial alternating current stimulation (HD-tACS) on patients with Non-suicidal Self-injury (NSSI) and its underlying neural mechanism by magnetic resonance imaging (MRI).

Eligibility

Min Age: 12 YearsMax Age: 18 Years

Inclusion Criteria3

The patients were diagnosed by 2 or more senior clinical psychiatrists, meeting DSM-V criteria, and having 1 or more non-suicidal self-injurious behaviors in the last 6 months.
-18 years of age.
The medicine has not changed in the 4 weeks prior to or after this study, and if it has to be changed, the treatment medication is required to be at a subtherapeutic dosage level.

Exclusion Criteria7

The patient has suicidal ideation or has committed suicidal behavior
T1 or T2 weighted phase magnetic resonance images show focal brain lesions
patients had neurological disorders such as epilepsy, or serious physical illnesses
patients had a history of substance abuse and drug dependence in the last 6 months or use of anticonvulsant drugs in the last 3 months
patients had received radial cranial electrical stimulation or magnetic stimulation treatment in the last 3 months or received electroconvulsive therapy in the last 6 months
patients had previous significant head trauma or EEG abnormality in the last 1 month
body-mounted devices unsuitable for treatment, such as pacemakers, artificial valves, and other metal implants.

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Interventions

DEVICEHigh-Definition Transcranial Alternating Current Stimulation (HD-tACS)

tACS is described as a non-invasive form of brain stimulation that uses a low-intensity, alternating current applied directly to the head through scalp electrodes.

DEVICEsham High-Definition Transcranial Alternating Current Stimulation (HD-tACS)

In the sham condition, tACS was delivered only during the ramp-up and ramp-down periods (15s and 15s); no current was delivered during the 20-minute intervention.