RecruitingNot ApplicableNCT07554755

TIS for NSSI in Adolescent Depression

Efficacy and Safety of Temporal Interference Stimulation on Non-suicidal Self-injury Behaviors in Adolescents With Depression

Sponsor

The Second Hospital of Anhui Medical University

Enrollment

60 participants

Start Date

Apr 30, 2026

Study Type

INTERVENTIONAL

Conditions

Temporal Interference Stimulation Major Depressive Disorder Non Suicidal Self Injury

Summary

Temporal Interference Stimulation (TIS) has been successfully used to help patients with depression. However, its role in alleviating self injuries remained uncertain. This trial will compare the effectiveness of TIS to a placebo control on non-suicidal self injury (NSSI) in patients with major depressive disorder(MDD).

Eligibility

Min Age: 12 YearsMax Age: 22 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Active Temporal Interference Stimulation (TIS) and a medical device called Sham Temporal Interference Stimulation (TIS) for people with major depressive disorder, non suicidal self injury, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 12 Years to 22 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEActive Temporal Interference Stimulation (TIS)

Active stimulation to the right subgenual anterior cingulate cortex; 2 sessions per day, 30 minutes per session, including a 30-second current ramp-up at the beginning and a 30-second ramp-down at the end, for 5-7 days.

DEVICESham Temporal Interference Stimulation (TIS)

Sham stimulation had only 30 seconds of current ramping-up and ramping-down at the beginning and end of the stimulation, respectively, to simulate the sensation of actual stimulation.