RecruitingNot ApplicableNCT06127342

Exercise and Emotional Learning in Posttraumatic Stress Disorder


Sponsor

Christal L Badour

Enrollment

100 participants

Start Date

May 13, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions. During the first experimental session, participants will undergo an MRI session of imaginal exposure to traumatic memory cues followed by 30-minutes of moderate intensity exercise or low intensity exercise. Participants will complete a second session of imaginal exposure with MRI 24 hours later.


Eligibility

Min Age: 18 YearsMax Age: 64 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying whether exercise can improve the brain's ability to process fear and fear extinction, and whether it reduces PTSD symptoms in adults who have experienced interpersonal violence (such as assault). It includes brain imaging (MRI) to track changes. **You may be eligible if:** - You are an adult (18+) with a diagnosis of PTSD related to interpersonal violence (e.g., physical or sexual assault) - You are physically able to exercise **You may NOT be eligible if:** - You have had severe substance use disorder in the past 3 months - You have had suicidal thoughts, psychotic episodes, or manic episodes in the past 3 months - You have significant developmental disabilities - You are currently taking benzodiazepines or stimulants daily and cannot stop for study sessions - You have recently changed psychiatric medications or started trauma-focused therapy (within 4 weeks) - You have a medical condition that prevents you from exercising - You have had a traumatic brain injury with loss of consciousness over 30 minutes - You have an MRI contraindication, a seizure disorder, or are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALModerate Intensity Exercise

Participants will wear a heartrate monitor and cycle on a stationary bike at a slow speed for 5 minutes, then slowly cycle on a stationary bike for 30 minutes, then cycle on the stationary bike at a slow speed for 5 minutes.

BEHAVIORALLow Intensity Exercise

Participants will wear a heartrate monitor and cycle on a stationary bike at a slow speed for 40 minutes.


Locations(2)

University of Kentucky

Lexington, Kentucky, United States

University of Texas

Austin, Texas, United States

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NCT06127342


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