RecruitingPhase 2NCT06128278

Acute Equol Supplementation and Vascular Function in Women With and Without CKD

Acute Equol Supplementation and Vascular Function in Postmenopausal Women With and Without CKD

Sponsor

University of Colorado, Denver

Enrollment

38 participants

Start Date

Mar 7, 2023

Study Type

INTERVENTIONAL

Conditions

Chronic Kidney Diseases Women Vascular Function

Summary

The risk of cardiovascular disease (CVD) is significantly elevated in patients with chronic kidney disease (CKD). Notably, women with CKD commonly experience menstrual disturbances induced by CKD, which may contribute to impaired vascular function and elevated CVD risk. However, most of the literature in nephrology focuses on male patients, and studies on women's vascular health are limited. Establishing effective therapies for improving vascular function and reducing CVD risk in women with CKD is a high research priority of the NIH. Equol contributes to improvement in vascular function, mediated in part by its anti-oxidative and anti-inflammatory properties. However, there is no information on the effect of equol on vascular function in women with CKD. The proposed project aims to determine the acute effect (1-hour, 2-hours, and 3-hours post ingestion) of oral equol supplementation on vascular function in postmenopausal women with and without CKD.

Eligibility

Sex: FEMALEMin Age: 50 YearsMax Age: 69 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying whether a supplement called equol (derived from soy) can improve blood vessel function in postmenopausal women, particularly comparing those with chronic kidney disease (CKD) to those without. **You may be eligible if:** - You are a postmenopausal woman aged 50–69 - You either have stage 3–4 chronic kidney disease (mildly reduced kidney function), OR - You are healthy with no kidney disease, high blood pressure, heart disease, or diabetes **You may NOT be eligible if:** - You currently use hormone replacement therapy (HRT) or used it for less than 6 months before enrolling - You need dialysis or have had a kidney transplant - You currently smoke or use nicotine, or have in the past 12 months - You have taken antioxidants or omega-3 supplements within the past 2 weeks - You have consumed soy products within 3 days of testing - You have atrial fibrillation, active infection, or were recently hospitalized Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.