Repeat Breast Conserving Surgery Followed by Daily Partial Breast Irradiation in Ipsilateral Breast

This trial is studying whether patients whose breast cancer has come back in the same breast after prior treatment can be successfully treated again with breast-conserving surgery (lumpectomy) followed by targeted partial breast radiation, rather than requiring full mastectomy. **You may be eligible if:** - You are over 18 with a confirmed recurrence of breast cancer in the same breast (DCIS or invasive cancer) - The recurrent tumor is smaller than 3 cm - It has been at least 3 years since you completed your prior course of whole breast radiation - Your surgical margins are negative (no cancer cells at the edges) - You have no evidence of distant spread (metastatic disease) - Your performance status is adequate (ECOG score 2 or less) and life expectancy is at least 12 months **You may NOT be eligible if:** - Your cancer has spread to lymph nodes or distant organs within 3 years of prior radiation - You have pure lobular carcinoma or multicentric cancer (tumors in different parts of the breast) - You have active skin involvement, Paget's disease, or scleroderma/dermatomyositis - You are pregnant or breastfeeding - You have a known BRCA1 or BRCA2 mutation Talk to your doctor to see if this trial is right for you.