RecruitingNot ApplicableNCT06132581

Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression

Sponsor

Florida State University

Enrollment

72 participants

Start Date

Jan 24, 2024

Study Type

INTERVENTIONAL

Conditions

Major Depressive Disorder Anhedonia

Summary

Anhedonia, the inability to seek-out and experience pleasure, is a common symptom in depression that predicts treatment-resistance and is sometimes exacerbated by first-line antidepressants. In our previous research, we found that anhedonia decreases goal-directed behavior and its related neural activity. In this study, we will investigate target engagement from five-consecutive days of stimulation for participants that are within a unipolar major depressive episode and also have high symptoms of anhedonia.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study uses brain stimulation and MRI to investigate whether a specific pattern of brain activity (called delta-beta coupling) plays a causal role in anhedonia — the inability to feel pleasure — in people with depression. Researchers want to understand what's happening in the brain during this symptom and whether targeted stimulation can improve it. **You may be eligible if...** - You are 18 to 65 years old - You have a diagnosis of major depressive disorder - You are experiencing significant inability to feel pleasure (anhedonia) - Your depression is at least moderate severity (measured by questionnaire) - You have mild or no suicidal thoughts - You are able to communicate in English **You may NOT be eligible if...** - You have epilepsy, a history of stroke, dementia, or Parkinson's disease - You have a metal implant in your body (pacemaker, cochlear implant, aneurysm clip) - You have a severe substance use disorder - You are pregnant - You have a moderate-to-severe bipolar disorder, psychotic disorder, or active serious substance use - You have had brain surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEDelta-beta tACS via the Neurocare Direct Current Stimulator Multi-Channel 4

DEVICETheta-gamma tACS via the Neurocare Direct Current Stimulator Multi-Channel 4

DEVICESham tACS via the Neurocare Direct Current Stimulator Multi-Channel 4

Stimulation will be delivered via the Neurocare Direct Current Stimulator Multi-Channel 4, an investigational electrical non-invasive brain stimulation device that is being used for foundational neuroscience and translational research. The electrical waveform is randomly selected to be the theta-gamma or delta-beta waveform, but the stimulation is delivered for only a brief period of time of approximately 30 seconds, which is not sufficient to produce a meaningful dose to the brain. This placebo, or sham, stimulation is designed to mimic the sensation of receiving stimulation.

Locations(1)

Florida State University

Tallahassee, Florida, United States

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Visit

NCT06132581

Related Trials

Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression

Conditions

Summary

Eligibility

Plain Language Summary

Interventions

Locations(1)

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