Anhedonia Clinical Trials

22 recruiting

Anhedonia Trials at a Glance

21 actively recruiting trials for anhedonia are listed on ClinicalTrialsFinder across 6 cities in 8 countries. The largest study group is Not Applicable with 13 trials, with the heaviest enrollment activity in Atlanta, Chapel Hill, and Bonn. Lead sponsors running anhedonia studies include Region Skane, Emory University, and University of North Carolina, Chapel Hill.

Browse anhedonia trials by phase

Treatments under study

About Anhedonia Clinical Trials

Looking for clinical trials for Anhedonia? There are currently 22 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Anhedonia trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Anhedonia clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 21 trials

Recruiting
Phase 4

Examining the Effects of Estradiol on Neural and Molecular Response to Reward

DepressionAnhedoniaPsychosis
University of North Carolina, Chapel Hill103 enrolled1 locationNCT05282277
Recruiting
Not Applicable

Psychotherapy Effects on Reward Processing in PTSD

Post Traumatic Stress DisorderAnhedoniaPTSD+3 more
University of Texas at Austin120 enrolled1 locationNCT06096740
Recruiting

Long-term Follow-up of Depressive Disorders in Psychiatric Care

DepressionPersonality DisordersAnhedonia+3 more
Region Skane415 enrolled2 locationsNCT07078227
Recruiting
Not Applicable

tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety

Healthy ParticipantsAnxiety Disorders (With High Anxiety Symptoms)Depressive Disorders (With High Anhedonia Symptoms)+1 more
Dr. Nils B. Kroemer104 enrolled1 locationNCT07476469
Recruiting
Not Applicable

Reward Processing and Exposure Therapy for Social Anxiety Disorder

AnhedoniaSocial Anxiety Disorder (Social Phobia)Public Speaking Anxiety+2 more
University of California, Los Angeles94 enrolled2 locationsNCT06776991
Recruiting

Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression

AnxietyAnhedoniaCognition+5 more
Riccardo Guglielmo100 enrolled5 locationsNCT07146503
Recruiting
Phase 1

Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects

Depression - Major Depressive DisorderAnhedonia
Medical University of Vienna85 enrolled1 locationNCT07490353
Recruiting
Not Applicable

Get ActivE Study for At-risk Youth

AnhedoniaDepression and Suicide Ideation
University of Pittsburgh75 enrolled2 locationsNCT06829953
Recruiting
Not Applicable

Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression

Major Depressive DisorderAnhedonia
Florida State University72 enrolled1 locationNCT06132581
Recruiting
Not Applicable

A Digitally Assisted Risk Reduction Platform for Youth at High Risk for Suicide

Mental Health DisorderSuicideAnhedonia
Ksana Health78 enrolled1 locationNCT05920252
Recruiting
Not Applicable

Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression

Anhedonia
The University of Texas Health Science Center, Houston45 enrolled1 locationNCT05240352
Recruiting
Phase 4

Dopaminergic Therapy for Anhedonia - 2

DepressionAnhedonia
Emory University70 enrolled1 locationNCT06075771
Recruiting
Not Applicable

Ecological Momentary Intervention for Reward in Anhedonia

DepressionStressAnxiety+1 more
Philipps University Marburg60 enrolled1 locationNCT07155941
Recruiting
Not Applicable

The Effect of Transcranial Direct Current Stimulation (tDCS) in Improving Emotion Health

AnhedoniaSubthreshold DepressionPositive Emotions+1 more
The University of Hong Kong90 enrolled1 locationNCT07319143
Recruiting
Not Applicable

TrueBlue Clinical Study - Investigating the Use of a Mobile Phone App TrueBlue for Monitoring Depression and Anxiety

DepressionAnxietyAnhedonia+3 more
BlueSkeye AI125 enrolled2 locationsNCT06364488
Recruiting
Not Applicable

Geolocation Positional System (GPS) Experience

DepressionEmotionsAnhedonia
University of Miami100 enrolled1 locationNCT05991713
Recruiting
Phase 3

Long-term Efficacy of Pramipexole in Anhedonic Depression

DepressionAnhedonia
Region Skane80 enrolled1 locationNCT05825235
Recruiting
Not Applicable

Stress Trajectories and Anhedonia in Adolescence Research Study

AnhedoniaAdolescent DevelopmentStress Response
University of North Carolina, Chapel Hill192 enrolled1 locationNCT07040449
Recruiting
Phase 2

Inflammation and Depression in People With HIV

DepressionAnhedoniaHIV
Emory University60 enrolled2 locationsNCT05849038
Recruiting

Reward Processing and Depressive Subtypes: Identifying Neural Biotypes

DepressionDepressive DisorderDepressive Symptoms+3 more
San Francisco Veterans Affairs Medical Center150 enrolled1 locationNCT06080646