Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

This study investigates whether giving a single infusion of infliximab — a drug that blocks an inflammatory protein called TNF-alpha — can improve thinking and memory problems (cognitive dysfunction) in people with major depression who also have high levels of inflammation in their blood. The study aims to understand the link between brain inflammation and depression-related cognitive difficulties. **You may be eligible if...** - You are 25 to 50 years old with a confirmed diagnosis of major depressive disorder - Your depression is at least moderate severity - Your blood shows an elevated inflammatory marker (CRP ≥ 3 mg/L) - You are either medication-free or on a stable antidepressant regimen for at least 4 weeks - You are willing to receive an IV infusion and have blood drawn **You may NOT be eligible if...** - You have a current or recent serious infection, chronic infection (HIV, hepatitis B/C), or active COVID-19 symptoms - You have a history of cancer, autoimmune disease, organ transplant, or severe liver problems - You are currently taking antipsychotics, anticonvulsants, or corticosteroids - You have bipolar disorder or a history of psychosis - You have significant suicidal ideation - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.