RecruitingPhase 2NCT06137274

Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC

Phase 2 Trial of Adaptive Radiotherapy Boost for Head and Neck Squamous Cell Carcinomas


Sponsor

H. Lee Moffitt Cancer Center and Research Institute

Enrollment

35 participants

Start Date

Dec 14, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of the study is to determine if it is feasible to use magnetic resonance imaging (MRI) to adjust a portion of radiation therapy for patients with head and neck squamous cell carcinoma . The technique under study will be used to personalize the study treatment based on response, keeping all treatments within standard of care guidelines.


Eligibility

Min Age: 18 Years

Inclusion Criteria8

  • Provision of signed and dated informed consent form
  • Stated willingness to comply with all study procedures and availability for the duration of the study
  • ECOG performance status of 0, 1
  • Patients with histologically or cytologically confirmed squamous cell carcinoma of the oral cavity, oropharynx, nasopharynx, hypopharynx, larynx, or unknown primary in the neck.
  • Patients with measurable disease, either at primary site or neck per RECIST 1.1.
  • For patients planned to receive chemotherapy, adequate hematologic, hepatic and renal function as outlined in protocol.
  • International normalized ratio of prothrombin time (INR) and prothrombin time (PT) within 28 days before randomization must be WNL for the lab. Patients who are therapeutically treated with an agent such as warfarin may participate if they are on a stable dose and no underlying abnormality in coagulation parameters exists per medical history.
  • Negative serum pregnancy test within before starting study treatment in woman with childbearing potential.

Exclusion Criteria5

  • Pregnancy or lactation
  • Patients who have had prior radiotherapy to the head and neck or prior systemic therapy for the index cancer.
  • Patients who had undergone definitive surgery for the index cancer.
  • Patients with distant metastatic disease
  • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, or psychiatric illness/social situations that would limit compliance with study requirements.

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Interventions

RADIATIONIntensity-modulated radiotherapy

All patients will be treated with intensity-modulated radiotherapy (IMRT) plans.

OTHERMagnetic Resonance Guidance

All patients will undergo combined CT and/or MR simulation and will be treated with a sequential-boost technique.


Locations(1)

Moffitt Cancer Center

Tampa, Florida, United States

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NCT06137274


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