RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS

This research study investigates how vagus nerve stimulation (VNS) — a treatment that sends mild electrical signals to the brain via a device implanted near the collarbone — affects brain function. It enrolls people with major depression or drug-resistant epilepsy who either already have a VNS device or are about to get one. **You may be eligible if...** - You are 18 or older - You have major depression or drug-resistant epilepsy - You either already have a VNS device implanted, or your doctor has recommended you get one - For depression: you have failed at least four different antidepressant treatments - Your medications have been stable for at least two months - You have health insurance and are willing to use a blood pressure cuff on your arm **You may NOT be eligible if...** - You have another type of implanted stimulation device - You are currently suicidal or have attempted suicide in the last 6 months - You have a psychotic disorder (like schizophrenia) or rapid cycling bipolar disorder - You have dementia or severe cognitive problems - You have active substance use disorder - You do not speak English - You have certain health conditions such as severe sleep apnea, COPD, or uncontrolled diabetes Talk to your doctor to see if this trial is right for you.