Metagenomic Next-Generation Sequencing Guides Anti-Infection Strategies

This study uses an advanced DNA sequencing technique (metagenomic next-generation sequencing) to identify the specific germs (bacteria, viruses, or fungi) causing infection in AIDS patients with severe pneumonia or septic shock, so that more targeted, effective antibiotic or antifungal treatments can be chosen. **You may be eligible if...** - You have confirmed HIV infection that has progressed to AIDS (CD4 count below 200 or an AIDS-defining illness) - You are between 18 and 65 years old - You have been diagnosed with severe pneumonia or septic shock **You may NOT be eligible if...** - You have a brain lesion, severe liver disease, or cirrhosis - You have an active tumor (cancer) - You are pregnant or breastfeeding - You have severe disease of the heart, lungs, liver, or kidneys - You have a history of alcohol or drug abuse - The researcher judges your overall condition would interfere with the study Talk to your doctor to see if this trial is right for you.