Regression of Cervical Precancerous Lesions and Associated Risk Factors
General University Hospital, Prague
300 participants
Sep 1, 2022
OBSERVATIONAL
Conditions
Summary
The aim of this study is to assess the extent of histopathological regression of severe cervical precancerous lesions (CIN 2 and CIN 3); evaluate the proportion of patients who experience the normalization of HPV test and cytology finding among those who were treated conservatively and those who underwent conization; and identify predictive parameters associated with regression. Based on this analysis, a model will be proposed to predict the likelihood of lesion regression.
Eligibility
Inclusion Criteria5
- squamocolumnar junction fully visualized
- bioptically verified CIN 2 or CIN 3
- age ≥ 18 years
- age ≤ 40 years
- informed consent
Exclusion Criteria8
- squamocolumnar junction not fully visualized
- suspicion on glandular lesion
- suspicion on invasive cancer
- personal history of CIN 2, 3 or cerv. cancer
- gravidity
- HIV positivity
- immunosuppression
- impossible photographic documentation
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Interventions
No surgery, observation
Locations(1)
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NCT06147388