HPV Clinical Trials

151 recruitingLast updated: June 18, 2026

There are 151 actively recruiting hpv clinical trials across 44 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1. Top locations include Chicago, Illinois, United States, New York, New York, United States, Houston, Texas, United States. Updated daily from ClinicalTrials.gov.


HPV Trials at a Glance

151 actively recruiting trials for hpv are listed on ClinicalTrialsFinder across 6 cities in 44 countries. The largest study group is Not Applicable with 51 trials, with the heaviest enrollment activity in Chicago, New York, and Houston. Lead sponsors running hpv studies include Emory University, M.D. Anderson Cancer Center, and Mayo Clinic.

Treatments under study

About HPV Clinical Trials

Looking for clinical trials for HPV? There are currently 33 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new HPV trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about HPV clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 151 trials

Recruiting
Phase 2

Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Locally Recurrent Head and Neck Squamous Cell CarcinomaLocally Recurrent Hypopharyngeal Squamous Cell Carcinoma+15 more
National Cancer Institute (NCI)180 enrolled70 locationsNCT07195734
Recruiting
Phase 1

Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma

Unresectable Head and Neck Squamous Cell CarcinomaStage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8+27 more
National Cancer Institute (NCI)39 enrolled1 locationNCT07156227
Recruiting
Phase 2

E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

Cervical CancerMetastatic CancerAnal Cancer+18 more
Christian Hinrichs20 enrolled3 locationsNCT05686226
Recruiting
Phase 1Phase 2

E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers

Cervical CancerAnal CancerPenile Cancer+14 more
Christian Hinrichs15 enrolled2 locationsNCT05639972
Recruiting
Not Applicable

Trial in HPV Prevention for the U.S. Vietnamese Community

HPV VaccinationHPV-related Cancers
Northwestern University96 enrolled1 locationNCT07637630
Recruiting
Not Applicable

Microvideos for Improving HPV Vaccination Among Childhood Cancer Survivors

HPV Vaccination
University of Utah55 enrolled1 locationNCT07648953
Recruiting
Not Applicable

Unidos Contra el VPH

Cervical CancersHuman Papilloma Virus (HPV)
University of Texas at Austin735 enrolled1 locationNCT06825689
Recruiting
Phase 2

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

Clinical Stage III Cutaneous Melanoma AJCC v8Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic Head and Neck Squamous Cell Carcinoma+22 more
National Cancer Institute (NCI)150 enrolled222 locationsNCT05136196
Recruiting
Phase 2

Evaluating a Decreased Dose of Radiation Therapy to the Elective Neck for the Treatment of HPV-Related Oropharyngeal Cancer, ENLIGHT Trial

Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Northwestern University100 enrolled2 locationsNCT07178301
Recruiting
Phase 3

A Study Comparing Personalized Radiation Therapy With Standard Radiation Therapy in People With HPV-Positive Throat Cancer

HPV-Related Squamous Cell Carcinoma
Memorial Sloan Kettering Cancer Center291 enrolled9 locationsNCT06563479
Recruiting
Not Applicable

Secondary Cervical Cancer Prevention of Vulnerable Women With HPV and HIV Co-infection in India

Cervical CancerHuman Papillomavirus (HPV) InfectionHuman Immunodeficiency Virus (HIV) Infection
University of California, Irvine348 enrolled3 locationsNCT07209917
Recruiting

The Natural History of Severe Viral Infections and Characterization of Immune Defects in Patients Without Known Immunocompromise

HPVHSVEBV+2 more
National Institute of Allergy and Infectious Diseases (NIAID)600 enrolled1 locationNCT01011712
Recruiting
Not Applicable

Stand Up 2 HPV: Standing Orders to Improve HPV Vaccination

HPV
University of Rochester16,000 enrolled1 locationNCT06380114
Recruiting
Not Applicable

Clinic vs Clinic+Community Outreach HPV Self-Collection to Increase Cervical Screening in Women With HIV

HIV InfectionsCervix CancerHPV Infection
UNC Lineberger Comprehensive Cancer Center7,597 enrolled1 locationNCT07428330
Recruiting
Not Applicable

Playing Game to Learn About Children's Vaccine Project

vaccine preventable diseasesHPV
Michigan State University180 enrolled1 locationNCT05984849
Recruiting
Phase 2

Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)

Squamous Cell CarcinomaHuman Papilloma Virus (HPV)Oropharyngeal Squamous Cell Carcinoma (OPSCC)
Medical University of South Carolina36 enrolled1 locationNCT07513389
Recruiting
Not Applicable

Empowering Vietnamese Americans

Cancer PreventionHPV Vaccination
Michigan State University60 enrolled1 locationNCT07164391
Recruiting
Phase 3

Palbociclib and Cetuximab Versus Cetuximab Monotherapy for Patients With CDKN2A-altered, HPV-unrelated Head and Neck Squamous Cell Carcinoma Who Experienced Disease Progression on a PD-1/L1 Inhibitor

HPV-unrelated Head and Neck Squamous Cell Carcinoma
Washington University School of Medicine81 enrolled5 locationsNCT04966481
Recruiting
Phase 1

Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer

Locally Advanced Head and Neck Squamous Cell CarcinomaClinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Stage III Hypopharyngeal Carcinoma AJCC v8+23 more
National Cancer Institute (NCI)46 enrolled18 locationsNCT05172245
Recruiting
Phase 2

Strengthening HPV Immunization Through EPI Leveraged Delivery

HPV Vaccine
International Vaccine Institute115 enrolled1 locationNCT07377656