RecruitingNCT06148467

Reverse Trigger Phenotypification and Response to Ventilatory Adjustments

Incidence of Reverse Trigger Phenotypes and Response to Ventilatory Adjustments in Patients With ARDS


Sponsor

Hospital Civil de Guadalajara

Enrollment

130 participants

Start Date

Nov 17, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this prospective observational study is to describe the incidence of reverse trigger (RT) in mechanically ventilated patients with diagnosis of acute respiratory distress syndrome (ARDS). The main questions it aims to answer are: * Real incidence of RT based on continuous monitoring * The response to mechanical ventilatiory adjustments Participants will be included as soon as neuromuscular blockers (NMB)/sedation is stopped or in case of spontaneous respiratory efforts detection, whatever happens first. Continuous monitoring will be performed by esophageal manometry until switch to a pressure support (spontaneous) mode, restart of deep sedation/neuromuscular blockers by medical indication, or death. In order to allow detection of possible RT in patients with ongoing sedation/NMB, mechanical ventilator waveforms will be screened every 1-2 hours by investigators and critical care physicians with at least 1 year of specific training in detection of dyssynchronies.


Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a new treatment for people with acute respiratory distress syndrome, mechanical ventilation, and other related conditions. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Hospital Civil Fray Antonio Alcalde

Guadalajara, Mexico

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NCT06148467


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