RecruitingPhase 3NCT06150560
A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)
A Phase III, Randomized, Double-Blind, Placebo Controlled Clinical Trial Evaluating the Benefits and Mechanism Of Action Of Angiotensin-II Receptor Blocker On Cardiovascular Remodeling In Patients With Repaired Coarctation Of Aorta
Sponsor
Mayo Clinic
Enrollment
120 participants
Start Date
Apr 1, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
Eligibility
Min Age: 18 Years
Inclusion Criteria4
- B/S1 hypertension
- SBP 100-139 average based on 3 office measurements.
- Age 18 or Older
- Previous COA Repair
Exclusion Criteria7
- Currently on beta blocker (BB) therapy
- Pregnancy/lactating
- eGFR\<30
- Hyperkalemia (serum potassium \>5.5mmol/L)
- Severe Aortic or Mitral valve stenosis or regurgitation
- Epicardial CAD diagnosis
- Received antihypertensive medications within the past year
Interventions
DRUGLosartan
50mg administered orally once daily for 52 weeks.
DRUGAmlodipine
5mg Amlodipine administered orally once daily for 52 weeks.
DRUGPlacebo
Oral capsules that contain no active drug ingredients administered orally once daily for 52 weeks.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06150560
Related Trials
Understanding the Health Effect of a Bioactive Peptide From Egg: A Pilot Study
NCT065553931 location
Innovative Tools to Expand Music-Inspired Strategies for Blood Pressure and Stroke Prevention
NCT073865351 location
Blood Pressure Care for Advancing Real-World Evidence (BPCARE)
NCT073983912 locations
Safest Choice of Antihypertensive Regimen for Postpartum Hypertension
NCT055511041 location
Effect of Electrical Stimulation and Exercise on Blood Flow in Patients With Resistant High Blood Pressure
NCT073832201 location