A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)

This trial (called the VALUE Trial) is studying whether a blood pressure medication called an angiotensin-II receptor blocker (ARB) can prevent or reverse cardiovascular changes in people who have had surgical repair of a narrowing of the aorta (called coarctation of the aorta, or COA). People who have had this repair often develop high blood pressure and heart changes later in life, and researchers want to see if ARBs can help. **You may be eligible if...** - You are 18 years or older - You have previously had surgical repair of coarctation of the aorta (COA) - You have mild to moderate high blood pressure (systolic blood pressure averaging 100–139 mmHg in the office) **You may NOT be eligible if...** - You are currently taking a beta-blocker medication - You are pregnant or breastfeeding - Your kidneys are not working well (eGFR below 30) - You have high potassium levels in your blood - You have severe aortic or mitral valve disease - You have a confirmed diagnosis of coronary artery disease - You have taken blood pressure medication in the past year Talk to your doctor to see if this trial is right for you.